I weighed in on this independent publishers discussion with the following comment:
This is good advice and matches what I learned with my first book, Discardia: More Life, Less Stuff.
Buy your own ISBN from Bowker (or, realistically, a group of 10 if you're also doing ebooks so you also have ISBNs for the EPUB and Kindle editions).
Sign up for Createspace and use them for their excellent prices on proof copies (also handy for creating review and Goodreads giveaway copies). Get your book looking great and prepare to build buzz. Do not use Createspace's Extended Distribution.
Sign up for Lightning Source (LSI) with the final version of your book now that you've done some proofing passes with cheaper copies from Createspace. Use LSI for reaching libraries and booksellers. Resign yourself to not making much money per copy through LSI and set the discount low enough that a bookseller will consider ordering from you. Bear in mind that LSI and Ingram or Baker & Taylor are both taking a cut out of that discount and that the bookseller also needs to cover their costs and make their profit in that slice. Once you add it up it's easy to see why booksellers aren't likely to even do special orders for something that's only got a 25% discount, especially if it's non-returnable.
Offer the Kindle version through Amazon's KDP program.
Offer EPUB versions through Apple's iTunes Connect and either (or both) Barnes & Noble's Nook Press and Google's Google Play. (Note: I have not yet published through the latter, but it is an alternative to the (in my experience) very low-selling Nook/BN.com world. If you want to reach a broader audience, it's important to have a non-Kindle, non-iTunes way for people to buy your EPUB edition, particularly if part of your audience prefers DRM-free books.
My second book, The Art of the Shim: Low-Alcohol Cocktails to Keep You Level, is full of great photography and, while the color print-on-demand (POD) quality from both Createspace and LSI was very much better than I expected, it's not yet "coffee-table book quality" and my partner and I have decided to use offset press printing. We still used Createspace for proof and review copies.